umwelt.medizin.gesellschaft 02/2025 (2. Quartal 2025)
Seite 14-18 - Neuartige Toxine in industrieller Nahrung (H.-U. Grimm)
1. Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
2. Michalsen, A., Bierhaus, A., Nawroth, P.P.et al.Glykotoxine und Zellaktivierung.Bundesgesundheitsbl.49, 773–779 (2006).
3 Ruiz HH, Ramasamy R, Schmidt AM. Advanced Glycation End Products: Building on the Concept of the "Common Soil" in Metabolic Disease. Endocrinology. 2020 Jan 1;161(1):bqz006. doi: 10.1210/endocr/bqz006. PMID: 31638645; PMCID: PMC7188081.
4. Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
5. ZhaoqingTian et. al: Dietary advanced glycation end products (dAGEs): An insight between modern diet and health. Food Chemistry, Volume 415, 2023,
6. Final Report Summary - ICARE (Impeding neo-formed Contaminants Accumulation to Reduce their Health Effects). European Union https://cordis.europa.eu/project/id/516415/reporting/deAbgerufen 21.03.2025
7. Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
8. Advanced Glycation Endproducts (AGEs). Advanced Glycation Endproducts (AGEs) sind Risikomoleküle für den Zellalterungsprozess. IMD Institut für Medizinische Diagnostik Berlin-Potsdam GbR https://www.imd-berlin.de/fachinformationen/diagnostikinformationen/advanced-glycation-endproducts-agesAbgerufen 21.3.2025
9. Yan, S., Ramasamy, R. & Schmidt, A. Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications.Nat Rev Endocrinol4, 285–293 (2008). https://doi.org/10.1038/ncpendmet0786
10. Twarda-Clapa, A.; Olczak, A.; Bia?kowska, A.M.; Kozio?kiewicz, M. Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs.Cells2022,11, 1312. https://doi.org/10.3390/cells11081312
11. Kyunghee Byun, YongCheol Yoo, Myeongjoo Son, Jaesuk Lee, Goo-Bo Jeong, Young Mok Park, Ghasem Hosseini Salekdeh, Bonghee Lee,Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases,Pharmacology & Therapeutics, Volume 177, 2017, Pages 44-55,
12. Jaime Uribarri, María Dolores del Castillo, María Pía de la Maza, Rosana Filip, Alejandro Gugliucci, Claudia Luevano-Contreras, Maciste H Macías-Cervantes, Deborah H Markowicz Bastos, Alejandra Medrano, Teresita Menini, Manuel Portero-Otin, Armando Rojas, Geni Rodrigues Sampaio, Kazimierz Wrobel, Katarzyna Wrobel, Ma Eugenia Garay-Sevilla: Dietary Advanced Glycation End Products and Their Role in Health and Disease, Advances in Nutrition, Volume 6, Issue 4, 2015, Pages 461-473
13. Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, Gugliucci A, Kapahi P. The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality. Cell Metab. 2018 Sep 4;28(3):337-352. doi: 10.1016/j.cmet.2018.08.014. PMID: 30184484; PMCID: PMC6355252.
14. Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li, Dietary advanced glycation end products (dAGEs): An insight between modern diet and health, Food Chemistry, Volume 415, 2023, 135735,
15. Ravichandran G, Lakshmanan DK, Raju K, Elangovan A, Nambirajan G, Devanesan AA, Thilagar S. Food advanced glycation end products as potential endocrine disruptors: An emerging threat to contemporary and future generation. Environ Int. 2019 Feb;123:486-500. doi: 10.1016/j.envint.2018.12.032. Epub 2019 Jan 5. PMID: 30622074.
16. Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li: Dietary advanced glycation end products (dAGEs): An insight between modern diet and health, Food Chemistry, Volume 415, 2023, https://doi.org/10.1016/j.foodchem.2023.135735.
17. Grafik https://www.sciencedirect.com/science/article/pii/S016372581730044X#f0005Kyunghee Byun, YongCheol Yoo, Myeongjoo Son, Jaesuk Lee, Goo-Bo Jeong, Young Mok Park, Ghasem Hosseini Salekdeh, Bonghee Lee: Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases, Pharmacology & Therapeutics, Volume 177, 2017, Pages 44-55
18. Byun K, Yoo Y, Son M, Lee J, Jeong GB, Park YM, Salekdeh GH, Lee B. Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases. Pharmacol Ther. 2017 Sep;177:44-55. doi: 10.1016/j.pharmthera.2017.02.030. Epub 2017 Feb 13. PMID: 28223234.
19. D'Cunha NM, Sergi D, Lane MM, Naumovski N, Gamage E, Rajendran A, Kouvari M, Gauci S, Dissanayka T, Marx W, Travica N. The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders. Nutrients. 2022 Jun 10;14(12):2421. doi: 10.3390/nu14122421. PMID: 35745150; PMCID: PMC9227209.
20. Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li, Dietary advanced glycation end products (dAGEs): An insight between modern diet and health, Food Chemistry, Volume 415, 2023,
21. Briceno Noriega D, Zenker HE, Croes CA, Ewaz A, Ruinemans-Koerts J, Savelkoul HFJ, van Neerven RJJ, Teodorowicz M. Receptor Mediated Effects of Advanced Glycation End Products (AGEs) on Innate and Adaptative Immunity: Relevance for Food Allergy. Nutrients. 2022 Jan 15;14(2):371. doi: 10.3390/nu14020371. PMID: 35057553; PMCID: PMC8778532.
22. Berni Canani R, Carucci L, Coppola S, D'Auria E, O'Mahony L, Roth-Walter F, Vassilopolou E, Agostoni C, Agache I, Akdis C, De Giovanni Di Santa Severina F, Faketea G, Greenhawt M, Hoffman K, Hufnagel K, Meyer R, Milani GP, Nowak-Wegrzyn A, Nwaru B, Padua I, Paparo L, Diego P, Reese I, Roduit C, Smith PK, Santos A, Untersmayr E, Vlieg-Boerstra B, Venter C. Ultra-processed foods, allergy outcomes and underlying mechanisms in children: An EAACI task force report. Pediatr Allergy Immunol. 2024 Sep;35(9):e14231. doi: 10.1111/pai.14231. PMID: 39254357.
23. Mouanness M, Nava H, Dagher C, Merhi Z. Contribution of Advanced Glycation End Products to PCOS Key Elements: A Narrative Review. Nutrients. 2022 Aug 30;14(17):3578.18. Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010 Jun;110(6):911-16.e12. doi: 10.1016/j.jada.2010.03.018. PMID: 20497781; PMCID: PMC3704564.
24. Bär, Ludmilla: Studies on the regulation of the phosphaturic hormone fibroblast growth factor 23 (FGF23) 2019, Diss Martin-Luther-Universität Halle-Wittenberg http://dx.doi.org/10.25673/13978
25. Wang L, Jiang Y, Zhao C. The effects of advanced glycation end-products on skin and potential anti-glycation strategies. Exp Dermatol. 2024 Apr;33(4):e15065. doi: 10.1111/exd.15065. PMID: 38563644.
26. Stylianos A. Kandarakis, Christina Piperi, Fotis Topouzis, Athanasios G. Papavassiliou, Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases, Progress in Retinal and Eye Research, Volume 42, 2014, Pages 85-102,
27. Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010 Jun;110(6):911-16.e12. doi: 10.1016/j.jada.2010.03.018. PMID: 20497781; PMCID: PMC3704564.
28. Xie Y, van der Fels-Klerx HJ, van Leeuwen SPJ, Fogliano V. Dietary advanced glycation end-products, 2-monochloropropane-1,3-diol esters and 3-monochloropropane-1,2-diol esters and glycidyl esters in infant formulas: Occurrence, formulation and processing effects, mitigation strategies. Compr Rev Food Sci Food Saf. 2021 Nov;20(6):5489-5515. doi: 10.1111/1541-4337.12842. Epub 2021 Oct 8. PMID: 34626078.
29. Grimm HU: Gesundes Essen für unsere Kinder: Was schädlich ist für sie und was ihnen gut tut. München: Droemer, 2019
30. Li Y, Wu Y, Quan W, Jia X, He Z, Wang Z, Adhikari B, Chen J, Zeng M. Quantitation of furosine, furfurals, and advanced glycation end products in milk treated with pasteurization and sterilization methods applicable in China. Food Res Int. 2021 Feb;140:110088. doi: 10.1016/j.foodres.2020.110088. Epub 2020 Dec 29. PMID: 33648304.
31. Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
32. Grimm HU: Information-Domination in the European Food Industry: Focus on Germany. In: Steier G., Patel K. (eds) International Food Law and Policy. Springer, Cham, 2017, S. 3 - 30
33.Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
34. Buetler, Timo & Latado, Helia & Scholz, Gabriele. (2013). Evidence for lipid signaling molecules in glycated protein preparations being responsible for the stimulation of inflammatory signaling in RAGE expressing cells - Potential role of lysophosphatidic acid. Toxicology Letters. 221. S120-S121. 10.1016/j.toxlet.2013.05.212.
35. Buetler, Timo & Latado, Hélia & Leclerc, Estelle & Weigle, Bernd & Baumeyer, Alexandra & Heizmann, Claus & Scholz, Gabriele. (2011). Glycolaldehyde-modified ?-lactoglobulin AGEs are unable to stimulate inflammatory signaling pathways in RAGE-expressing human cell lines. Molecular nutrition & food research. 55. 291-9. 10.1002/mnfr.201000140.
36. Buetler, Timo & Latado, Hélia & Baumeyer, Alexandra & Delatour, Thierry. (2008). Dicarbonyls Stimulate Cellular Protection Systems in Primary Rat Hepatocytes and Show Anti-inflammatory Properties. Annals of the New York Academy of Sciences. 1126. 113-7. 10.1196/annals.1433.036.
37. Buetler, Timo & Leclerc, Estelle & Baumeyer, Alexandra & Latado, Helia & Newell, John & Adolfsson, Oskar & Parisod, Véronique & Richoz, Janique & Maurer, Sarah & Foata, Francis & Piguet, Dominique & Junod, Sylviane & Heizmann, Claus & Delatour, Thierry. (2008). N?-Carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response. Molecular nutrition & food research. 52. 370-8. 10.1002/mnfr.200700101.
38. Nicole J. Kellow, Melinda T. Coughlan, Effect of diet-derived advanced glycation end products on inflammation,Nutrition Reviews, Volume 73, Issue 11, November 2015, Pages 737–759,
39.Bü?ra Demirer, Gülhan Samur, Possible effects of dietary advanced glycation end products on maternal and fetal health: a review,Nutrition Reviews, Volume 81, Issue 7, July 2023, Pages 844–856
40.Katrien Van Puyvelde, Tony Mets, Rose Njemini, Ingo Beyer, Ivan Bautmans, Effect of advanced glycation end product intake on inflammation and aging: a systematic review,Nutrition Reviews, Volume 72, Issue 10, 1 October 2014, Pages 638–650,https://doi.org/10.1111/nure.12141
41 Hellwig M, Diel P, Eisenbrand G, Grune T, Guth S, Henle T, Humpf HU, Joost HG, Marko D, Raupbach J, Roth A, Vieths S, Mally A. Dietary glycation compounds - implications for human health. Crit Rev Toxicol. 2024 Sep;54(8):485-617. doi: 10.1080/10408444.2024.2362985. Epub 2024 Aug 16. PMID: 39150724.
42. Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
43. van Tulleken C, Rollins N, Coombes R. Conflicts of interest: moving towards zero tolerance. BMJ. 2024 Nov 19;387:q2574. doi: 10.1136/bmj.q2574. PMID: 39562036.
44. Li Y, Zheng X, Guo J, Samura M, Ge Y, Zhao S, Li G, Chen X, Shoji T, Ikezoe T, Miyata M, Xu B, Dalman RL. Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice. J Am Heart Assoc. 2023 May 16;12(10):e028081. doi: 10.1161/JAHA.122.028081. Epub 2023 May 9. PMID: 37158066; PMCID: PMC10227285.
45. Reddy VP, Aryal P, Soni P. RAGE Inhibitors in Neurodegenerative Diseases. Biomedicines. 2023 Apr 9;11(4):1131. doi: 10.3390/biomedicines11041131. PMID: 37189749; PMCID: PMC10136230.
46. Systems Biology of Human Aging Network Model 2019, Biochemical and Physiological Interactions. Legendary Pharmaceuticals. http://www.legendarypharma.com/chartbg.htmlAbgerufen 21.3.2025
47. Peters, M. J., R. Joehanes, L. C. Pilling, C. Schurmann, K. N. Conneely, J. Powell, E. Reinmaa, et al. 2015. "The transcriptional landscape of age in human peripheral blood.” Nature Communications 6 (1): 8570. doi:10.1038/ncomms9570. http://dx.doi.org/10.1038/ncomms9570.
48. Shumilina J, Kusnetsova A, Tsarev A, Janse van Rensburg HC, Medvedev S, Demidchik V, Van den Ende W, Frolov A. Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling? Int J Mol Sci. 2019 May 13;20(9):2366. doi: 10.3390/ijms20092366. PMID: 31086058; PMCID: PMC6539852.
49. Semba RD, Nicklett EJ, Ferrucci L. Does accumulation of advanced glycation end products contribute to the aging phenotype? J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):963-75. doi: 10.1093/gerona/glq074. Epub 2010 May 17. PMID: 20478906; PMCID: PMC2920582.
50. Rowan S, Bejarano E, Taylor A. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3631-3643. doi: 10.1016/j.bbadis.2018.08.036. Epub 2018 Aug 29. PMID: 30279139; PMCID: PMC6822271.
51. Michalsen, A., Bierhaus, A., Nawroth, P.P.et al.Glykotoxine und Zellaktivierung.Bundesgesundheitsbl.49, 773–779 (2006).
52. Schwarzenbolz U, Hofmann T, Sparmann N, Henle T. Free Maillard Reaction Products in Milk Reflect Nutritional Intake of Glycated Proteins and Can Be Used to Distinguish "Organic" and "Conventionally" Produced Milk. J Agric Food Chem. 2016 Jun 22;64(24):5071-8. doi: 10.1021/acs.jafc.6b01375. Epub 2016 Jun 8. PMID: 27213835.
53. Li Y, Peng Y, Shen Y, Zhang Y, Liu L, Yang X. Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases. Crit Rev Food Sci Nutr. 2023;63(29):9816-9842. doi: 10.1080/10408398.2022.2076064. Epub 2022 May 19. PMID: 35587161.
54. González I, Morales MA, Rojas A. Polyphenols and AGEs/RAGE axis. Trends and challenges. Food Res Int. 2020 Mar;129:108843. doi: 10.1016/j.foodres.2019.108843. Epub 2019 Dec 3. PMID: 32036875.
55.Reddy, V. & Aryal, Puspa. (2023). RAGE Inhibitors in Neurodegenerative Diseases. Biomedicines. 11. 1131. 10.3390/biomedicines11041131.
56. Qian Zhou, Ka-Wing Cheng, Jianbo Xiao, Mingfu Wang,The multifunctional roles of flavonoids against the formation of advanced glycation end products (AGEs) and AGEs-induced harmful effects, Trends in Food Science & Technology, Volume 103, 2020, Pages 333-347,
57. Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021 May;14(5):46. doi: 10.3892/br.2021.1422. Epub 2021 Mar 18. PMID: 33786175; PMCID: PMC7995243.
58. Shinichi Sugiura,Yumeno Iwata,Sae Hirano,Momoka Nagano,Mayako Uchida,Mika Asano,Hirotaka Akita,Effect of red wine on AGEs in blood,Glycative Stress Research,2023,Volume 10,Issue 4,Pages 164-170,
59. Oliveira JS, da Silva JA, de Freitas BVM, Alfenas RCG, Bressan J. A Mediterranean diet improves glycation markers in healthy people and in those with chronic diseases: a systematic review of clinical trials. Nutr Rev. 2025 Feb 1;83(2):e317-e331. doi: 10.1093/nutrit/nuae045. PMID: 38719207.
1 Schweisfurth H. Umweltschadstoff Ozon. Dtsch Med Wschr 1994; 119: 351-355.
2 Schöttes C, Schweisfurth H, Voshaar T. Smog 1984 - 1987. Morbidität an respiratorischen und kardiovaskulären Erkrankungen in Gelsenkirchen. Atemw-Lungenkrkh 1989; 15: 15-19.
3 Schweisfurth H. Beeinflussung der Atemwege durch Luftschadstoffe (SO2, NOx und O3). Allergo J 1996; 5: 339-345.
4 Schweisfurth H. Feinstaub und pulmo-kardiale Erkrankungen. Atemw-Lungenkrkh 2014; 40: 435-441.
5 Preiss P, Roos J, Friedrich R. Assessment of health impacts of coal fired power stations in Germany – by applying eco sense web, Universität Stuttgart 2013.
6 Zacher W. Umwelt und Gesundheit. Gefahr aus Kohlekraftwerken. Dtsch Ärztebl 2015; 112: A1178-1180.
7 Umweltbundesamt. Feinstaubbelastung in Deutschland, Mai 2009. http://www.umweltbundesamt.de/publikationen/feinstaubbelastung-indeutschland.
8 WHO. Press Release 221,17. October 2013. http://www.iarc.fr/en/mediacentre/pr/2013/pdfs/pr221_E.pdf.
9 Umweltbundesamt. Warum ist Feinstaub schädlich für den Menschen? 05.09.2013. http://www.umweltbundesamt.de/service/uba-fragen/warumist-feinstaub-schaedlich-fuer-den-menschen.
10 39. Verordnung zur Durchführung des Bundes-Immissionsschutzgesetzes:Verordnung über Luftqualitätsstandards und Emissionshöchstmengen – 39. BImSchV vom 02.08.2010 und https://eur-lex.europa.eu/legal-content/DE/TXT/?uri=CELEX:32008L0050#ntr4-L_2008152DE.01002401-E0004.
12 Faustini A, Stafoggia M, Colais P et al. On behalf of the EPIAIR collaborative Group. Air pollution and multiple acute respiratory outcomes. Eur Respir J 2013; 42: 304-313.
13 Tramuto F, Cusimano R, Cerame G et al. Urban air pollution and emergency room admissions for respiratory symptoms: a case-crossover study in Palermo, Italy. Environ Health 2011; 10: 31.
14 Sato R, Gui P, Ito K, Kohzuki M, Ebihara S. Effect of short-term exposure to high particulate levels on cough reflex sensitivity in healthy tourists: A pilot
study. Open Respir Med J 2016; 10: 96-104.
15 Salvi S. Health effects of ambient air pollution in children. Paediatr Respir Rev 2007; 8: 275–280.
16 Umweltbundesamt. Indikator: Gesundheitsrisiken durch Feinstaub. https://www.umweltbundesamt.de/indikator-gesundheitsrisiken-durch-feinstaub, 14.11.2017.
17 Abbey DE, Nishino N, McDonnell WF et al. Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. Am J Respir Crit Care Med 1999; 159: 373–382.
18 Laden F, Schwartz J, Speizer FE, Dockery DW. Reduction in fine particulate air pollution and mortality: extended follow-up of the Harvard Six Cities study. Am J Respir Crit Care Med 2006; 173: 667–672.
19 Pope CA, Burnett RT, Thun MJ et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 2002; 287:
1132–1141.
20 Raaschou-Nielsen O, Andersen ZJ, Beelen R et al. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol 2013; 14: 813-822.
21 Dimakopoulou K, Samoli E, Beelen R et al. Air pollution and non-malignant respiratory mortality in 16 cohorts within the ESCAPE project. Am J Respir Crit Care Med 2014; 189: 684-696.
22 Beelen R, Raaschou-Nielsen O, Stafoggia M et al. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European
cohorts within the multicentre ESCAPE project. Lancet 2014; 383: 785-795.
23 Shah AS, Langrish JP, Nair H et al. Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet 2013; 382: 1039-1048.
24 Cesaroni G, Forastiere F, Stafoggia M et al. Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort
study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ 2014; 348: f7412.
25 Wang M, Beelen R, Stafoggia M et al. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int 2014; 66: 97-106.
26 Raaschou-Nielsen O, Pedersen M, Stafoggia M et al. Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts. Int J Cancer 2017; 140: 1528-1537.
27 Tallon LA, Manjourides J, Pun VC et al. Erectile dysfunction and exposure to ambient Air pollution in a nationally representative cohort of older men. Environ Health 2017; 16: 12.
28 Forastiere F, Agabiti N. Assessing the link between air pollution and heart failure. Lancet 2013; 382: 1008-1010.
29 Dennekamp M, Abramson MJ. The effects of bushfire smoke on respiratory health. Respirology 2011; 16: 198-209.
30 Finlay SE, Moffat A, Gazzard R et al. Health impacts of wildfires. PLoS Curr 2192: 4: 4f959951cce2c.
31 Viswanathan S, Eria L, Diunugala N et al. An analysis of effects of San Diego wildfire on ambient air quality. J Air Waste Manag Assoc 2006; 56: 56-67.
32 Schweisfurth H. Klimawandel und Krankheit, Nora Verlagsgemeinschaft, Berlin 2014.
33 Analitis A, Georgiadis I, Katsouyanni K. Forest fires are associated with elevated mortality in a dense urban setting. Occup Environ Med 2012; 69: 158-162.
34 Mirabelli MC, Künzli N, Avol E et al. Respiratory symptoms following wildfire smoke exposure: airway size as a susceptibility factor. Epidemiology 2009; 20: 451-459.
35 Ovadnevaite J, Kvietkus K, Marsalka A. 2002 summer fires in Lithuania: impact on the Vilnius city air quality and the inhabitants health. Sci Total Environ 2006; 356: 11-21.
37 Dadvand P, Parker J, Bell ML et al. Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity. Environ Health Perspect 2013; 121: 267-373.
38 Pedersen M, Giorgis-Allemand L, Bernard C et al. Ambient air pollution and low birthweight: a European cohort study (ESCAPE). Lancet Respir Med 2013; 1: 695-704.
39 Zhu PF, Zhang Y, Ban J et al. Air pollution and adverse birth outcome in China: a comprehensive review. Zhonghua Liu Xing Bing Xue Za Zhi 2017; 38: 393-399.
40 Woodward NC, Pakbin P, Saffari A et al. Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity
for CA1 neurons. Neurobiol Aging 2017; 53: 48-58.
41 Brook JR, Burnett RT, Dann TF et al. Further interpretation of the acute effect of nitrogen dioxide observed in Canadian time-series studies. J Expo Sci Environ Epidemiol 2007; 17(suppl 2): S36–S44.
42 Valavanidis A, Fiotakis K, Vlachogianni T. Airborne particulate matter and human health: toxicological assessment and importance of size and composition
of particles for oxidative damage and carcinogenic mechanisms. J
Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2008; 26: 339–362.
43 Umweltbundesamt. Telegramm Umwelt und Gesundheit 01 2016. https://www.umweltbundesamt.de/sites/default/files/medien/360/dokumente/telegramm_
01_2016_stickstoffdioxid.pdf, 03.03.2016.
44 He Q, Wu SL, Xu F et al. The relationship between the potential years of life lost of lung cancer and air pollution in Wuhan. Zhonghua Liu Xing Bing Xue
Za Zhi 2007; 28: 1175-1178.
45 Lu X, Yao T, Li Y et al. Source apportionment and health effect of NOx over the Pearl River Delta region in southern China. Environ Pollut 2016; 212: 135-146.
46 Hamra GB, Laden F, Cohen AJ et al. Lung cancer and exposure to nitrogen dioxide and traffic: a systematic review and meta-analysis. Environ Health
Perspect 2015; 123: 1107-1112.
47 Wei Y, Yazdi D, Ma T et al. Additive effects of 10-year exposures to PM2.5 and NO2 and primary cancer incidence in American older adults. Environ
Epidemiol 2023; 7: e265 und Korrektur e270.
48 Breitner S, Steckling-Muschack N, Markevych I. Quantifizierung der Krankheitslast verursacht durch Ozon-Exposition in Deutschland für die Jahre 2007-2016. Umwelt & Gesundheit 6/23. Hrsg. Umweltbundesamt, Dessau-Roßlau 2023.
49 Zhang J, Wei Y, Fang, Z. Ozone pollution: a major health hazard worldwide.Front Immunol 2019; 10: 2518.
50 Vicedo-Cabrera AM, Sera F, Liu C et al. Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries.
Br Med J 2020; 368: m108.
51 Gu J, Shi Y, Zhu Y et al. Ambient air pollution and cause-specific risk of hospital admission in China: a nationwide time-series study. PLoS Med 2020; 17: e1003188.
52 US EPA. Health effects of ozone pollution. https://www.epa.gov/ground-levelozone-pollution/health-effects-ozone-pollution, 09.04.2024.
53 Achebak H, Garatachea R, Pay MT et al. Geographic sources of ozone air pollution and mortality burden in Europe. Nat Med 2024; 30: 1732–1738.
54 The Economic Consequences of Outdoor Air Pollution, OECD Publishing, Paris. 2016. http://dx.doi.org/10.1787/9789264257474-en
55 Air pollution to cause 6-9 million premature deaths and cost 1 % GDP by 2060. http://www.oecd.org/env/air-pollution-to-cause-6-9-million-prematuredeaths-
and-cost-1-gdp-by-2060.htm, 30.03.2017.
56 Umweltbundesamt. https://www.umweltbundesamt.de/sites/default/files/medien/5750/publikationen/hgp_luftqualitaet_2020_bf.pdf, 01.07.2024.
58 Umweltbundesamt. Trend der PM10 -Jahresmittelwerte, 2023.
